To provide you with the most relevant and helpful information, and understand which The https:// ensures that you are connecting to the Milk thistle can trigger allergic reactions. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: How To Make Sense of a Scientific Journal Article, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Milk Thistle | NCCIH Milk thistle is sometimes used to treat skin conditions including mild psoriasis. While more research into milk thistle, silymarin, and its effectiveness in treating OCD is definitely needed, there is a wealth of information supporting the other health benefits of milk thistle for a host of ailments: Liver Health It is believed that milk thistle and silymarin bolsters liver function by prohibiting toxic substances from binding to liver cells (6). include protected health information. Recent research has explored the use of milk thistle. Not only does this help prevent cirrhoris, but may also be advantageous for those living with hepatitis or other liver diseases. Research Breakdown on Milk Thistle - Examine Advertising revenue supports our not-for-profit mission. You should not use this product if you are allergic to milk thistle or if you have: past or present cancer of the breast, uterus, or ovary; or. Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). One study questioned the benefits of milk thistle for liver diseases. But the evidence is limited, and some research methodologies are flawed, so its difficult to confirm these effects. Anxiety; Autophagy; BDNF; Depression; Silibinin. Neurological Disorders Milk thistle has long been used to alleviate the inflammation commonly associated with a host of neurological disorders such as dementia, Alzheimers, and Parkinsons Disease (8). information highlighted below and resubmit the form. Phytother Res. Cochrane Database Syst Rev. World J Gastroenterol. Uses of Lavender: Everything You Need to Know, 11 Popular Natural Remedies for the Common Cold, Natural Remedies for Alcohol Use Disorder, The therapeutic potential of milk thistle in diabetes, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. Questions? The information and products shown on this website should not be interpreted as a substitute for physician evaluation or treatment. Borah A, Paul R, Choudhury S, Choudhury A, Bhuyan B, Das Talukdar A, Dutta Choudhury M, Mohanakumar KP. 2013 Nov;19(11):847-53. doi: 10.1111/cns.12175. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Subjects were assessed with the National Institute of Mental Health Trichotillomania Severity Scale (primary outcome), the Massachusetts General Hospital Hair Pulling Scale, Clinical Global Impression scale, and measures of depression, anxiety, and psychosocial . JAMA. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. This content does not have an Arabic version. Receive the latest, most useful health and wellness articles, tips, special discounts on nutritional supplements and so much more. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Available for Android and iOS devices. Some supplements are close to chemicals in efficacy like saffron (standardized extract) for depression and magnolia bark extract for anxiety. Version: 2.01. In test-tube and animal studies, silymarin has been shown to prevent oxidative damage to brain cells, which could help prevent mental decline (16, 17). The Gale Encyclopedia of Alternative Medicine, second edition, 2004. Side effects. Silymarin: not just another antioxidant - PubMed All rights reserved. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; This is not a complete list of side effects and others may occur. 3 Milk thistle may change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Over the Counter & Complementary Therapies | Parkinson's Foundation Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. and depression. Together, you can make shared, well-informed decisions. 2 skintightspandex 3 yr. ago Ya idk I've taken milk thistle for liver health and I have anxiety independent of it Nootropicsfan 3 yr. ago . And, most recently, milk thistle is gaining traction as a natural remedy to help manage the symptoms of OCD. Phytomedicine. Depression and anxiety are associated with increased risk of developing AD. Milk thistle (Silybum marianum) is a flowering plant belonging to the Asteraceae (daisy) family. Milk thistle products appear to help the skin heal from damage caused by UVB radiation from the sun and may offer benefits in preventing non-melanoma skin cancers. 2014;97 Suppl 11:S31-S40. In fact, it has traditionally been used to treat liver and gallbladder disorders, promote breast milk production, prevent and treat cancer and even protect the liver from snake bites, alcohol and other environmental poisons. Users are advised to seek the advice of their physician or other qualified health care provider with any questions you may have regarding a medical condition. The research on milk thistle's use in cancer patients is promising, although more research is needed to determine its benefits. Call your doctor if the condition you are treating with milk thistle does not improve, or if it gets worse while using this product. If youre pregnant or breastfeeding, check with your doctor before using milk thistle. Milk thistle - Mayo Clinic Also notable is the fact that, of the 40 subjects that completed this trial, none had any adverse events or side effects with milk thistle supplementation (7). Find out more on the side effects of statins. Cathy Wong is a nutritionist and wellness expert. Multiple Myeloma vs. Leukemia: What Are the Differences? 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. It could interact with many drugs, including some that treat high cholesterol, infections, insomnia, and blood pressure. 2020 Feb;47(2):302-312. doi: 10.1111/1440-1681.13201. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Liu HY, Wei HJ, Wu L, Liu SM, Tang YY, Zou W, Wang CY, Zhang P, Tang XQ. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. information submitted for this request. Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Milk thistle is currently used for the treatment of toxin-induced liver injury, for its inhibition of progressive hepatic fibrosis and the prevention of cirrhosis, for its antifibrogenic effects in alcohol-induced cirrhosis and for modulation of insulin resistance. Epub 2013 Oct 14. Am J Gastroenterol. Era of Hope Meeting for the Department of Defense Breast Cancer Research Program, Atlanta, June 8-11, 2000. Can You Get Milk Thistle Naturally From Foods? MeSH However, evidence suggests that milk thistle extracts might be useful in the treatment of mood disorders. Effects of Silybum marianum (L.) Gaertn. Milk thistle is most often used for various liver conditions, like hepatitis and fatty liver disease. Now, one substance that we know can inhibit 5-alpha reductase, although it does it pretty weakly, is saw palmetto [200-500mg/Day, 2-3 . Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Phytother Res. FOIA There are no other food sources of this herb. It also states that Milk Thistle will lower Ferritin and that iron-supplement is advised. Malaria. If you take any medicines regularly, talk to your doctor before you start using milk thistle. WebMD does not provide medical advice, diagnosis or treatment. One reported effect of milk thistle is that it can boost breast milk production in lactating mothers. #1: Milk thistle detoxifies the liver. 2. But experts say that the evidence isnt conclusive. Milk Thistle: Health Benefits, Safety Information, Dosage, and More - WebMD The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. Using different formulations together increases the risk of an overdose. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, The 10 Best Herbs for Liver Health: Benefits and Precautions, How to Get Rid of Acne: 14 Home Remedies for Pimples. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in people with type 2 diabetes. Silymarin is an antioxidant compound taken from milk thistle seeds. Milk Thistle: Benefits, Uses, Side Effects, and More Biomed Res Int. Fried, M.; Navarro, V.; Afdhal, N. et al. 5 It was found that there was no significant difference between milk thistle and Prozac for OCD symptoms. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Milk thistle has been an important natural remedy for centuries of folk medicine practitioners. The nutritional content varies for each brand, so be sure to . Milk thistle seems to have few side effects, even when taken for several years. . Summary One study has shown that people taking milk thistle supplements experienced a decrease in the number of acne lesions on their body. This article reviews what milk thistle is and, Milk thistle tea is said to protect the liver, stimulate breast milk production, and lower blood sugar levels. Call 911 or seek help right away if you experience severe side effects from taking milk thistle. https://www.wolterskluwercdi.com/facts-comparisons-online/. Protective Effect of Silibinin on Learning and Memory Impairment in LPS-Treated Rats via ROS-BDNF-TrkB Pathway. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. Other SSRIs on the market include Fluvoxamine (Luvox), Paroxatine (Paxil), and Sertraline (Zoloft) (3). Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. Consult with a licensed healthcare professional before using any herbal/health supplement. Research shows that the silymarin in milk thistle helps protect the liver from many industrial toxins, such as carbon tetrachloride. Theres some evidence that milk thistle can treat cirrhosis and chronic hepatitis, which can be caused by alcohol abuse, autoimmune disease, or viruses. Milk thistle can cause severe allergic reaction and anaphylaxis, a rare but potentially life-threatening allergic reaction. Dosage and side effects. Written by Cerner Multum. Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. Matutino Santos P, Pereira Campos G, Nascimento C. Neuropsychiatr Dis Treat. Milk thistle has long been utilized as an anti-inflammatory agent offering numerous benefits to our liver, cholesterol, cardiovascular health, menopause symptom relief, and even gallbladder disorders. Copyright 2017 Elsevier Inc. All rights reserved. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. 2014;2014:941085. doi:10.1155/2014/941085. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. https://www.micromedexsolutions.com. While not dangerous, it can cause scars. Although rare, milk thistle may trigger a number of common and mild side effects. While milk thistle has been traditionally used in pregnant and breastfeeding women, its safety is unknown. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Before . Front Immunol. No supplement is intended to treat, cure, or prevent disease. It may also make chemotherapy work more effectively against certain cancers and, in some circumstances, even destroy cancer cells (9, 29, 30, 31). Since milk thistle may lower blood sugar, people with diabetes should check with their doctor before taking the herb as it may make their blood sugar fall too low. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Hepatology. Effects of Silybum marianum (L.) Gaertn. The terms milk thistle and silymarin are often used interchangeably. Do not give any herbal/health supplement to a child without medical advice. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . Some people are advised to be cautious when taking milk thistle. Eur Endocrinol. This article will explore the uses of milk thistle and research on its potential benefits. 2023 Jan 26;15:997054. doi: 10.3389/fnmol.2022.997054. I have bad anxiety, mild depression and obsessive thoughts - Reddit Historically, people have used milk thistle for liver disorders and gallbladder problems. Osteoporosis is a disease caused by progressive bone loss. Milk thistle has been shown in experimental test-tube and animal studies to stimulate bone mineralization and potentially be protective against bone loss (22, 23). Learn more about natural remedies for type 2 diabetes. Liver Detoxification and Health. Side effects are always possible when taking supplements. In fact, in studies where high doses were used for long periods, only about 1% of people experienced side effects (1). People who have diabetes or endometriosis should check with a doctor before using milk thistle. Summary The active ingredients in milk thistle have been shown in animals to improve the effects of some cancer treatments. Advanced Milk Thistle, 120 softgels - Life Extension Accessed Oct. 30, 2020. Why does zinc cause anxiety and depression for some people? One small clinical trial showed an increase in breast milk formation in humans using milk thistle, but researchers caution that more studies are needed. Song X, Zhou B, Cui L, Lei D, Zhang P, Yao G, Xia M, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Onodera S, Ikejima T. Neurochem Res. Feng N, Luo J, Guo X. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. 2023 Natural Wellness. Overall, more high-quality research is needed to define the doses and clinical effects of this fascinating herb. The benefits of milk thistle remain unclear for this purpose and the limited research on milk thistle and breast milk has been done primarily in animals. DISCUSSION: Why do I feel better with Milk Thistle? Well go over the methods that doctors use to determine this and provide a chart, Blessed thistle is an herb with a long history of use for digestive issues and breastfeeding. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. Taken in appropriate doses, oral use of milk thistle appears to be safe. For example, in one study, researchers investigated the mood elevating effects of silymarin, a collection of phytochemicals extracted from milk thistle. In some cases it may be useful in treating these cancers, but studies have yet to fully demonstrate the safety and efficacy of milk thistle use. Tajmohammadi A, Razavi BM, Hosseinzadeh H. The study researchers hypothesize that milk thistle's antioxidant qualities make it a good candidate for treating conditions like cancer, hepatitis, NAFLD, diabetes, depression, and heart disease. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs.

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