The name of the prescribing practitioner. This medicine is available in four forms: capsules, disintegrating tablets, extended-release capsules, and tablets. the unsubscribe link in the e-mail. Some of the studies that have linked Phentermine to positive results in humans include: The main active ingredient is known as Phentermine Hydrochloride. Phentermine is approved for use for up to 12 . This website is a resource which lists doctors and clinics who may offer phentermine or appetite suppressants for patients they deem qualified. hWmo8+jE'"m{F (1) A pharmacist, in good faith and in the course of professional practice only, may dispense controlled substances upon a written, oral, or electronic prescription of a practitioner, under the following conditions: (a) Oral prescriptions must be promptly reduced to writing by the pharmacist or recorded . hb```e````a`d`@ f(fcfILLvL~. The FDA has categorized this drug as X for pregnancy, which means it should not be used during pregnancy under any circumstances. Phentermine is contraindicated during pregnancy because weight loss offers no potential benefit to a pregnant woman and may result in fetal harm. Patients with a larger body weight may need to take a larger dose, depending on whether they have any health concerns that may be worsened by the usage of a larger dose. While discussing the use of Phentermine with the doctor, a patient is provided a list of lifestyle changes to implement while using this product. 0000002493 00000 n In relatively short-term clinical trials, adult obese subjects instructed in dietary management and treated with anorectic drugs lost more weight on the average than those treated with placebo and diet. Phentermine Hydrochloride Tablets are indicated only as short-term (a few weeks) monotherapy for the management of exogenous obesity. 97-102; s. 301, ch. Concomitant use of alcohol with phentermine may result in an adverse drug reaction. Ask your healthcare professional how you should dispose of any medicine you do not use. This search engine indexes the Drug Enforcement Administration Diversion Control Program Web Site (www.deadiversion.usdoj.gov) only. As mentioned above, new mothers should avoid using this medication when breastfeeding. Do not keep outdated medicine or medicine no longer needed. Generic name: Phentermine hydrochloride Long-term efficacy and safety of anti-obesity treatment: Where do we stand? SECTION 04. In fact, one study conducted at the Duke University School of Medicine found that apart from the Phentermines ability to effectively reduce body weight, it can also help improve a patients health-related quality of life. Intravenous phentolamine (Regitine, CIBA) has been suggested on pharmacologic grounds for possible acute, severe hypertension, if this complicates overdosage. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). It should melt quickly. %%EOF 138 0 obj <>stream After 12 weeks, the patient needs to take a break from the product as it may lead to physical dependence. Your email address will not be published. Perreault L. Obesity in adults: Drug therapy. 0000002991 00000 n The possible origins of the increased weight loss due to the various drug effects are not established. Make sure your hands are dry before touching the tablet. Primary Pulmonary Hypertension (PPH) a rare, frequently fatal disease of the lungs has been reported to occur in patients receiving a combination of Phentermine with fenfluramine or dexfenfluramine. Click here for an email preview. We comply with the HONcode standard for trustworthy health information. Phentermine is not a miracle drug taken daily and the body simply starts losing weight all by itself. Florida Statutes Definitions Index (2022), Table Tracing Session Laws to Florida Statutes (2022), Index to Special and Local Laws (1971-2022), Index to Special and Local Laws (1845-1970). REGULATION OF PROFESSIONS AND OCCUPATIONS. The amount of medicine that you take depends on the strength of the medicine. i h,T h,T +h,T h,T 6B*CJ aJ mH nH ph u+h,T h,T B*CJ H*aJ mH nH ph u(h,T h,T B*CJ aJ mH nH ph u +h,T h,T 5B*CJ aJ mH nH ph u ~ P r 2 i $ hhhh hd 1$ 5$ 7$ 8$ 9D H$ `ha$gd,T $d 1$ 5$ 7$ 8$ 9D H$ a$gd,T " $ hhhh hd 1$ 5$ 7$ 8$ 9D @&H$ `ha$gd,T i gd,T $d x 1$ 5$ 7$ 8$ 9D H$ a$gd,T 2 1h:p,T / =!"#$% @ @ @ N o r m a l CJ _HaJ mH sH tH D A@ D D e f a u l t P a r a g r a p h F o n t R i R T a b l e N o r m a l 4 1591 0 obj <>stream NDC 42806-810-01 The least amount feasible should be prescribed or dispensed at one time in order to minimize the possibility of overdosage. This content does not have an Arabic version. Amphetamines and other stimulant drugs have been extensively abused and the possibility of abuse of Phentermine should be kept in mind when evaluating the desirability of including a drug as part of a weight reduction program. While the drug is considered to be relatively safe for individuals who are older than 16, the recommended age is 18. For example, it can be be used with healthy eating, physical activity and behavior change. Your doctor may prescribe both of these drugs separately, or choose to prescribe Qsymia, which is another medication that combines Phentermine and Topamax. %%EOF To avoid trouble with sleeping, take the last dose of the day about 4 to 6 hours before bedtime, unless your doctor tells you otherwise. Law Implemented Florida Statutes 458.336. Javascript must be enabled for site search. xref 104 0 obj <> endobj (In combination with a healthy diet and exercise plan). Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for. In some cases, the doctor may prescribe Phentermine in smaller doses and advise the patient to take it up to three times in a single day. To provide you with the most relevant and helpful information, and understand which Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. It is a class IV controlled substance because of its serious side effects and addiction potential. information is beneficial, we may combine your email and website usage information with W0Qxe {>x??}# cGCSGGC[G(P A@3'i~ (2[n! Today, Phentermine can still be obtained through the doctors prescription in the majority of countries around the world. There is a problem with The overdose symptoms include: The side effects of Phentermine can lead to several symptoms that may impair certain functions in the patients body. As phentermine is similar to amphetamine, it is a controlled drug (class C5) and has the potential for abuse. The Administration's plan is to end the COVID-19 public health emergency on May 11, 2023. The amount of weight loss associated with the use of an anorectic drug varies from trial to trial, and the increased weight loss appears to be related in part to variables other than the drugs prescribed, such as the physician-investigator, the population treated and the diet prescribed. Phentermine also is offered combined with topiramate for weight loss (Qsymia). If the doctor finds that the patient is a good candidate for Phentermine, they may prescribe a certain dose and provide specific details on dosage and lifestyle choices that should accompany the use of this medicine. Six years after the approval, a similar drug, called Aminorex, were released in Europe with the same purpose of helping obese individuals. IBM Micromedex. Animal reproduction studies have not been conducted with Phentermine. A pharmacist may not dispense a controlled substance listed in Schedule II, Schedule III, or Schedule IV to any patient or patients agent without first determining, in the exercise of her or his professional judgment, that the order is valid. Phentermine is most commonly prescribed to patients who experience negative health effects to excessive amounts of body weight. Won Son J, et al. The Topamax is added to Phentermine in order to intensify its effects and to help patients lose weight faster. Some patients need to take the drug an hour before they eat breakfast, while others are advised to take it approximately one to two hours after breakfast. In some cases, the use of this drug in combination with other pills may cause the effects of other drugs to increase. 1558 0 obj <>/Filter/FlateDecode/ID[<7182559B062CF74D9CEE71C953F61692>]/Index[1530 62]/Info 1529 0 R/Length 121/Prev 89015/Root 1531 0 R/Size 1592/Type/XRef/W[1 2 1]>>stream 0000003317 00000 n In some cases, patients have also found that Phentermine interacts with drugs that contain Tranylcypromine, Henelzine, Isocarboxazid, Diethylpropion, Phendimetrazine, Amphetamine, and Benzphetamine. The use of Topamax and Phentermine is actually an FDA-approved combination. startxref Phentermine Hydrochloride Tablets are indicated as a short-term (a few weeks) adjunct in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction in the management of exogenous obesity for patients with an initial body mass index 30 kg/m2, or 27 kg/m2 in the presence of other risk factors (e.g., controlled hypertension, diabetes, hyperlipidemia). This is a label given to drugs that can be misused. The doctor also looks at the patients medical history for any pre-existing medical conditions that the medication should not be taken with. Comprehensive review of current and upcoming anti-obesity drugs. Package insert / product label Overstimulation, restlessness, dizziness, insomnia, euphoria, dysphoria, tremor, headache, psychosis. Phentermine has pharmacologic activity similar to amphetamine (d- and dll-amphetamine) [see Clinical Pharmacology (12.1)]. It is vital to talk with the doctor before using Phentermine with other products. endstream endobj startxref You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Studies do not permit conclusions as to the relative importance of the drug and non-drug factors on weight loss. Over 12 weeks, it can be as high as 9-10%. BMI is calculated by taking the patients weight, in kilograms (kg), divided by the patients height, in meters (m), squared. hYr ~{L(QdK4^bdsO_d;a BXO--p,!4!,WhfM/@c . l 4 a ( k ( N o L i s t ( z ) . LZ(6&JQKU5@5_M.~#p = yLgzP"Z90* v~1iu0pV (s:J&Q,. } }& 8}q>u@y)dO|fRmknw huA0@6-%&k-1qI6fSt4#>=sHMk>8fztq9_ nw:>NxHfib Lx.c QEWg\@y@ ~[*+-Dze~Ej+%.E`|IdW#o~#` MM health information, we will treat all of that information as protected health While these are the most common side effects of the drug, they are not the only consequences associated with the intake of this medication. 0000005652 00000 n The drug is classified under a certain chemical class known as amphetamine as it has a similar pharmacology value to other drugs classified in the class. 0000000016 00000 n History.s. Drugs of this class used in obesity are commonly known as anorectics or anorexigenics. It has not been established that the primary action of such drugs in treating obesity is one of appetite suppression since other central nervous system actions, or metabolic effects, may also be involved. It has the chemical name of ,,-Dimethylphenethylamine hydrochloride. This content does not have an English version. Patients who have been on a Phentermine program should not suddenly stop using the drug. Tablets are packaged in bottles of 100 (NDC 42806-810-01); and 1000 (NDC 42806-810-10). CRIMES. Initial U.S. Approval: 1959 -----INDICATIONS AND USAGE----- Suprenza is a sympathomimetic amine anorectic indicated as a short-term adjunct (a few weeks) in a regimen of . They inhibit the activity of an entire enzyme family known as monoamine oxidase. Numerous side effects have been linked to the use of Phentermine. The PDMP was created in the 2009 session of the Florida legislature to encourage safer prescribing of controlled substances and reduce drug abuse and diversion within the state. The most common side effects that patients experience include tremors, headaches, dizziness, dry mouth, diarrhea, constipation, upset stomach, feeling restless and being hyperactive. Both the law and the rule for treating obesity outline practice guidelines for the safe use of phentermine, fenfluramine, and ot her drugs used to . 2020; doi:10.4093/dmj.2020.0258. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Burguera B, et al. By: Susan St. John Pursuant to Section 456.44(3)(a), Florida Statutes, and Rule 64B-9.013(3)(a), Florida Administrative Code, a practitioner must evaluate a patient by taking a complete medical history and performing a physical examination prior to prescribing a controlled substance to a patient. To provide you with the most relevant and helpful information, and understand which This includes prescription and nonprescription (over-the-counter) medicines, dietary supplements, herbal remedies, or medicines for appetite control, asthma, colds, cough, hay fever, and sinus problems. Mayo Clinic Proceedings. In order to determine the effectiveness of certain pharmaceuticals, supplements and other substances, clinical trials and scientific research are often conducted among a group of volunteers. The dosage varies from 15mg to 37.5mg per day. What to offer the 99% of patients with severe obesity who do not undergo bariatric surgery? The doctor may advise the patient to complete the remaining period of the program or help him/her end the program safely. This combination of ingredients was branded as Fen-Phen. Phentermine is for people with obesity or overweight who haven't been able to lose enough weight with diet and exercise alone to improve their health. Do not crush, break, or chew it. privacy practices. The natural history of obesity is measured over several years, whereas the studies cited are restricted to a few weeks duration; thus, the total impact of drug-induced weight loss over that of diet alone must be considered clinically limited. The strength and dosage of Phentermine depend on the brand that is prescribed and the patients specific condition. Publications, Help Searching Patients must be informed that Phentermine hydrochloride is a short-term (a few weeks) adjunct in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction in the management of exogenous obesity, and that coadministration of Phentermine with other drugs for weight loss is not recommended [see Indications and Usage (1) and Warnings and Precautions (5.1)]. Instead of simply quitting the program, a patient should rather consult a healthcare provider about quitting. Precaution should be taken if a patient has any existing health concerns as the drug may cause further harm to their body. law states . Phentermine: 18.75 to 37.5 milligrams (mg) once a day, taken before breakfast or 1 to 2 hours after breakfast. 0000002736 00000 n ZeS{$d!YS,|C~E;h4DJS?|{x}~ ?`2F. The combined drug is approved for long-term use. Selling or giving away Phentermine may harm others and is against the law. Common side effects of phentermine include: Phentermine is one of the most prescribed weight-loss medicines. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. Last updated on Mar 22, 2023. The number of such prescription, as recorded in the prescription files of the pharmacy in which it is filled. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. This does not only include prescription drugs but also: Common drugs that are known to interact with Phentermine include Dopamine, Venlafaxine, Linezolid, Ephedrine, Isoproterenol, Epinephrine, Norepinephrine and a Phenylephrine injection. Phentermine doctors network. s. 4, ch. Schedule. 2012 Florida Statutes. Such prescriptions must contain the date of the oral authorization. Carefully follow your doctor's instructions for a reduced-calorie diet plan and regular exercise. Phentermine (as resin complex): Usual dosage is 15 or 30 mg once daily. As much as 33% of the U.S. adult population are considered to be obese. 893.04 Pharmacist and practitioner.. The goal of the drug is to help patients lose weight and increase energy since the withdrawal symptoms of include fatigue and weight gain through an increase in appetite, the product is rendered a waste of the patients time and money. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Of course, it is taken orally. hbbd``b` @IHpA\> . A reduction in insulin or oral hypoglycemic medications in patients with diabetes mellitus may be required. Such controlled substances may be sold only upon an order form, when such an order form is required for sale by the drug abuse laws of the United States or this state, or regulations pursuant thereto. If your dose is different, do not change it unless your doctor tells you to do so. This documentation contains information regarding prescribing in Florida and is an effort to highlight Florida laws and rules related to prescribing in one doc ument. (A) A prescriber may utilize a schedule III or IV controlled substance for the treatment of obesity only if it has an F.D.A approved indication for this purpose and then only in accordance with all of the . Yes, you need a prescription for phentermine. (phentermine hydrochloride) orally disintegrating tablet C IV . Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Unfortunately, patients experienced a variety of side effects, which included severe heart toxicity and hypertension. The aforementioned statute and rule do not specifically rule out a patient evaluation taking place . Phentermine is not recommended for use in pediatric patients 16 years of age. Due to its status as a controlled substance, the sale, distribution, and possession of this drug . Doctors often prescribe a dose of 5-HTP and vitamin B12 with a Phentermine prescription in order to enhance its effects and to relieve some side effects. If you take too much of this medicine, it may become habit-forming (causing mental or physical dependence). House Bill 831 (2019), Electronic Prescribing, was signed into law by Governor DeSantis. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG. A pharmacist may not knowingly fill a prescription that has been forged for a controlled substance listed in Schedule II, Schedule III, or Schedule IV. Fatigue and depression usually follow the central stimulation. information highlighted below and resubmit the form. Portions of this document last updated: Feb. 01, 2023. Copyright: Merative US L.P. 1973, 2023. Following the administration of Phentermine, Phentermine reaches peak concentrations (Cmax) after 3 to 4.4 hours. Phentermine is a Schedule 4 drug. Each written prescription prescribed by a practitioner in this state for a controlled substance listed in Schedule II, Schedule III, or Schedule IV must include both a written and a numerical notation of the quantity of the controlled substance prescribed on the face of the prescription and a notation of the date, with the abbreviated month written out on the face of the prescription. Chapter 893 DRUG ABUSE PREVENTION AND CONTROL Entire Chapter. If the federal government fails to oversee how the money is spent, advocates worry it will be wasted. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Talk with your doctor before starting an exercise program. Doctors often advise patients that in the case of more serious side effects, they should immediately call for assistance. There shall appear on the face of the prescription or written record thereof for the controlled substance the following information: The full name and address of the person for whom, or the owner of the animal for which, the controlled substance is dispensed. The initials of the pharmacist filling the prescription and the date filled. Typical actions of amphetamines include central nervous system stimulation and elevation of blood pressure. The bill provides important new requirements for prescribers to generate and transmit all prescriptions electronically upon licensure renewal or by July 1, 2021, whichever is earlier. Phentermine is a Schedule IV controlled substance. Some of these include: As with many other prescription drugs, Phentermine can also interact with certain medications. Use caution in prescribing Phentermine for patients with even mild hypertension (risk of increase in blood pressure). Phentermine has not been studied in patients with eGFR less than 15 mL/min/1.73m2, including end-stage renal disease requiring dialysis; avoid use in these populations. All rights reserved. Adults and children 17 years of age and older. Phentermine. The journals or printed bills of the respective chambers should be consulted for official purposes. Taking more than the prescribed amount of Phentermine can lead to an overdose, which means if a patient misses a dose, they should never try to make up for it by taking more than the prescribed amount at the next dose. 75-18; s. 12, ch. Adjust dosage according to individual response and tolerance; use the smallest dosage required to produce the desired response. information and will only use or disclose that information as set forth in our notice of Controlled substances for the treatment of obesity. HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use . All rights reserved. other information we have about you. (d) each prescription writtenby a practitioner in this statefor a controlledsubstance listed in schedule ii, schedule iii, or schedule iv must include a writtenand a numerical notation of the quantity of the controlled substance prescribed and a notation of the datein numerical, month/day/year format, or with the abbreviated month writtenout, or the month writtenout in . Before starting with consumption of this medication, patients should get informed about potential adverse effects to be able to determine whether a newly-developed symptom is a sign of a health issue or just a side effect associated with Phentermine. Follow your doctor's dosing instructions very carefully. The structural formula is as follows: Phentermine hydrochloride is a white, odorless, hygroscopic, crystalline powder which is soluble in water and lower alcohols, slightly soluble in chloroform and insoluble in ether. Phentermine is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, amphetamine (d- and dll-amphetamine). Follow your doctor's orders or the directions on the label. Tablets containing 37.5 mg Phentermine hydrochloride (equivalent to 30 mg Phentermine base). See Drug Abuse and Dependence (9) and Overdosage (10). Registration is accomplished by completing and returning the dispensing physician registration form. If we combine this information with your protected For more FAQs, please see our full archive of Frequently Asked Questions about phentermine and related prescription appetite suppressants. endstream endobj 105 0 obj <> endobj 106 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI]>>/Rotate 0/Type/Page>> endobj 107 0 obj <>stream Florida Statutes Definitions Index (2022), Table Tracing Session Laws to Florida Statutes (2022), Index to Special and Local Laws (1971-2022), Index to Special and Local Laws (1845-1970). Drug information provided by: Merative, Micromedex. Management of acute Phentermine hydrochloride intoxication is largely symptomatic and includes lavage and sedation with a barbiturate. Symptoms of extremely high blood pressure, such as uneven heartbeats, chest pain, blurred vision, anxiety and a severe headache. Dosage form: tablet 1530 0 obj <> endobj A clear, concise warning that it is a crime to transfer the controlled substance to any person other than the patient for whom prescribed. privacy practices. 893.049(1)(d), (e),f.s. A minimum weight gain, and no weight loss, is currently recommended for all pregnant women, including those who are already overweight or obese, due to obligatory weight gain that occurs in maternal tissues during pregnancy. 2019; doi:10.1016/j.mayocp.2018.11.020. During the COVID-19 public health emergency (PHE), authorized providers can prescribe controlled substances via telehealth, without the need for an in-person medical evaluation. Even after the period that the drug has been prescribed for, the doctor will often recommend to gradually stop using the Phentermine to avoid the withdrawal symptoms.