Over time, lindane is broken down in soil, sediment and water into less harmful substances by algae, fungi and bacteria; however, the process is relatively slow and dependent on ambient environmental conditions. WebLindane is released into the environment during and after agricultural application through volatilization into the atmosphere (estimated at 12-30%), where it has long-range transport potential and can be deposited by rainfall. Dizziness. Lindane is moderately toxic to mammals and may be a neurotoxin. (e) MARINE POLLUTANT mark. [11][12] Both medications contain only the gamma-HCH isomer, and are available as prescription-only medications. Read what you need to know about our industry portal chemeurope.com. (ii) 5 kg (11 pounds) or less net capacity for solids. (1) On single packagings or combination packagings where each single package or each inner packaging of combination packagings has: (i) A net quantity of 5 L (1.3 gallons) or less for liquids; or, (ii) A net mass of 5 kg (11 pounds) or less for solids. [20] The majority of studies of the general population have also shown no association between serum or breast tissue levels of lindane and breast cancer. %%EOF Gives off irritating or toxic fumes (or gases) in a fire. [30][31]The US FDA continues to maintain that lindane medications have necessary health benefits that outweigh potential risks and should remain available for patients with head lice, scabies and pubic lice (crabs) who have few treatment alternatives. Medical observation is indicated. <<77808EBE95D8C749B7A9AFF580CD8412>]>> Effects of short-term exposure It is also a recognised irritant. In humans, lindane primarily affects the nervous system, liver and kidneys, and may be a carcinogen and/or endocrine disruptor.[1][2]. WebLINDANE ICSC: 0053 IMPORTANT DATA PHYSICAL STATE; APPEARANCE: ODOURLESS, WHITE CRYSTALLINE POWDER CHEMICAL DANGERS: On contact with hot surfaces or flames this substance decomposes forming toxic and corrosive fumes including phosgene and hydrogen chloride. 0000003791 00000 n Vomiting. A harmful concentration of airborne particles can be reached quickly when dispersed. Environmental Protection Agency (EPA) The mark must be visible from the direction it faces. WebLindane is an organochlorine pesticide belonging to persistent organic pollutants (POPs) that has been widely used to treat agricultural pests. Six cases of congenital anomaly were also describedfive for infants "possibly" exposed to lindane in utero and one paternal exposurebut no characteristic pattern of effect was noted. Store in an area without drain or sewer access. WHITE CRYSTALLINE POWDER. [1] Adverse hematologic effects have also been reported with chronic occupational exposures and excessive dermal applications; however, a direct cause and effect has not been established. Lindane has adverse effects on Convulsions. Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance, chemical protection suit including self-contained breathing apparatus and protective gloves. UN Hazard Class: 6.1; UN Pack Group: III, Prepared by an international group of experts on behalf of ILO and WHO, The following ingredients are of concern in the marine environment and need more testing: Cinoxate. The companys promotion agreement with Alliant Pharmaceuticals, which commenced in 2005, was terminated May 2007. [4] Lindane has not been manufactured in the U.S. since the mid-1970s but continues to be imported and formulated for restricted use. [25] In 2002, the EPA concluded that lindane agricultural products were eligible for re-registration given industry compliance with certain data and labeling requirements to mitigate occupational risks to workers. Hepatic cytochrome P-450 oxygenase system. Electronic Code of Federal Regulations (e-CFR), Subtitle B - Other Regulations Relating to Transportation, CHAPTER I - PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION, SUBCHAPTER C - HAZARDOUS MATERIALS REGULATIONS, PART 172 - HAZARDOUS MATERIALS TABLE, SPECIAL PROVISIONS, HAZARDOUS MATERIALS COMMUNICATIONS, EMERGENCY RESPONSE INFORMATION, TRAINING REQUIREMENTS, AND SECURITY PLANS. Depending on the degree of exposure, periodic medical examination is suggested. Abstract. The most common side effects are nonserious reactions of the skin (e.g., burning, itching, dryness and rash). However, lindane medications remain available in Canada for public health purposes as non-prescription therapies. Cyanobacteria are able to tolerate, and even metabolize, moderate doses of organochlorine pesticides, such as lindane (γ-hexachlorocyclohexane), one of the most persistent and widely used in recent decades. The World Health Organization classifies lindane as "moderately hazardous", and its international trade is restricted and regulated under the Rotterdam Convention on Prior Informed Consent. In 2009, the production and agricultural use of lindane was banned under the Stockholm Convention on persistent organic pollutants. 0000002858 00000 n In the U.S., lindane medications are exclusively manufactured and distributed by Morton Grove Pharmaceuticals, Inc. [1][19] The most common side effects with topical use of lindane medications are nonserious reactions of the skin, including burning, itching, dryness and rash. Exposure could cause death. Your browser does not support JavaScript. Well closed. (c) A transport vehicle or freight container that contains a package subject to the marking requirements of paragraph (a) or (b) of this section must be marked with the MARINE POLLUTANT mark. WebInternational initiatives on Lindane include the Protocol on Persistent Organic Pollutants of the Convention on Long Range Transboundary Air Pollution; the Rotterdam Convention; the OSPAR Commission for the Protection of the Marine Environment of the Northeast Atlantic, the Great Refer for medical attention. (B) Bulk packages with a capacity of less than 3,785 L (1,000 gallons); or. The direct causes of death for the other cases were attributed to reasons other than lindane. 0000057176 00000 n (d) The MARINE POLLUTANT mark is not required -. Not combustible. 0000047710 00000 n [27] Similar findings were noted by U.S. Geologic Survey teams in 1999 and 2000. 0000001466 00000 n Lindane persists in the environment and bioaccumulates as an organochlorine pesticide and can pose risks to ecological environments and human The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. (3) Transitional exception. [1] The ecological impact of lindanes environmental persistence continues to be debated. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. To use all functions of this page, please activate cookies in your browser. [16] Only rarely have seizures and even more rarely fatal reactions been reported when lindane medications were used (presumably) according to directions.[7][11][12]. $>. Headache. The mark may be displayed in black lettering on a square-on-point configuration having the same outside dimensions as a placard; or. Ethyl-4-aminobenzoate. trailer Do not transport with food and feedstuffs. The substance may cause effects on the central nervous system. People who are occupationally exposed to it are advised to avoid its [7] Worldwide, effective treatment options for the control of scabies and lice are relatively limited. However, a significant amount of Lindane is also found in This produces toxic and corrosive fumes including hydrogen chloride and trichlorobenzenes (see ICSCs 0344, 1049 and 1222). ];pGvZo~z8i##N7M3|cruvx}qLY^*PqoWU-;yr$z:9~sro?6N9iC0Y 6)?S9xwQ(elU[3+s]q-{ The EPA has approved the use of lindane stockpiles through 2009. 0000003168 00000 n "[14], The most common side effects associated with topical use of lindane medications are nonserious reactions of the skin, including burning, itching, dryness and rash. [1][21] Similarly, no increased cancer risk was noted in a large epidemiologic study of lindane medications involving a 143,594-patient database with up to 21 years of follow up, which concluded that There is still no persuasive evidence from studies of humans that lindane, as ordinarily used clinically, is carcinogenic in humans. [22] Current as of October 03, 2022 | Updated by FindLaw Staff. Find out how LUMITOS supports you with online marketing. Where two or more components that make a material a marine pollutant are present, the names of at least two of the components most predominantly contributing to the marine pollutant designation must appear in parentheses in association with the marked proper shipping name. Lindane has been used in the U.S. for more than 60 years, both in healthcare and in agriculture. Symbol (fish and tree): Black on white or suitable contrasting background. WebIn the case of marine pollutants also meeting the criteria for inclusion in another hazard class, all provisions of this subchapter relevant to any additional hazards continue to 104 22 Further see Ingestion. [3] It is presently banned in more than 50 countries, and is being considered for inclusion in the Stockholm Convention on persistent organic pollutants, which would ban its production and use worldwide. hYio+QB L` EDl+b?5 %U`{W5=;" C*LOu3],5K1v)v..%S]*&dc?>|]^+}.{|xu}>_]_og|Sn6?8WagnsyY~9,6lY|y /7buvx|~\^sgd_ yr|t1g/7o_7:E}stm"(:KjuygEwq^|_]. (Note: These events represent the most common reported to the FDA and do not represent the most common events associated with the use of lindane lotion and lindane shampoo overall). Marine pollutants or environmentally hazardous substances are materials that can pose a risk to aquatic ecosystems. Marine pollutant is a term mainly used by IMDG code while the term " environmentally hazardous substances " are used by other dangerous goods regulations such as ADR and IATA. 1997-2023 LUMITOS AG, All rights reserved, https://www.chemeurope.com/en/encyclopedia/Lindane.html, Your browser is not current. The authors concluded that "The California experience suggests elimination of pharmaceutical lindane produced environmental benefits, was associated with a reduction in reported unintentional exposures and did not adversely affect head lice and scabies treatment. Give a slurry of activated charcoal in water to drink, but NOT if convulsions occur. Boiling point: 323C Melting point: 113C Density: 1.9 g/cmSolubility in water, g/100ml at 20C: 0.0007 (very poor)Vapour pressure, Pa at 20C: 0.0012 Relative density of the vapour/air-mixture at 20C (air = 1): 1Octanol/water partition coefficient as log Pow: 3.61 - 3.72. The Persistent Organic Pollutants Review Committee of the Stockholm Convention on Persistent Organic Pollutants considers the use of lindane in agriculture as largely redundant, with other, less toxic and less persistent pesticides. Aurora is best viewed in areas without light pollution and no cloud cover. That's what the Environmental Protection Agency said after downgrading ozone standards in the northern front range from "serious" to "severe." [6] (see also Regulatory Status) The FDA, however, continues to support the use of lindane prescription medications, noting that The risk of occupational/environmental exposure should be assessed separately and independent of the risk related to the therapeutic use of a medication to treat a medical condition where there is direct benefit to the patient. Fish, marine mammals and birds in the region are exposed to environmental pollutants, increasing the stress of the marine ecosystem. A marking in conformance with the requirements of this paragraph in effect on December 31, 2014, may continue to be used until December 31, 2016. (2) Be marked on each end and each side with the MARINE POLLUTANT mark if the packaging has a capacity of 3,785 L (1,000 gallons) or more. [4][5] This is not unlike other medications where the active ingredient has other non-healthcare applications. 0000003484 00000 n The company seeks damages and injunctive relief against all of the defendants. [7][11][12] [16] (see also Pharmaceutical Uses) Indeed, most of the adverse human health effects reported for lindane have related to agricultural uses and chronic, occupational exposure of seed treatment workers to agricultural-grade lindane. Reacts with bases. Code of Federal Regulations Title 49. 0000006477 00000 n Web4-methylbenzylidene camphor. WebLindane is considered to be highly toxic to aquatic organisms, and moderately toxic to birds and mammals. 0 104 0 obj <> endobj WebLindane Can Be Toxic to Humans Lindane, also known as g-hexachlorocyclohexane (g-HCH), is commonly used in shampoos and other topical treatments for head lice and Lindane (Persistant Organic Pollutant) in the EU, Best Practices of De-Contamination Exchanged. [23] However, more recent evaluations by subject matter experts do not support this rating. Purpose Hexachlorocyclohexane (HCH) isomers (-, - and - (Lindane)) were recently included as new persistent organic pollutants (POPs) in the Stockholm Convention, and therefore, the legacy of HCH and Lindane production became a contemporary topic of global relevance. Carefully collect remainder. This substance does enter the environment under normal use. Separated from bases and food and feedstuffs. It is highly toxic to fish and honeybees and moderately toxic to most The study also documented a marked decrease in lindane wastewater contamination and lindane poisoning incidents reported to Poison Control Centers. To explore the toxic effects of lindane and the underlying mechanisms of this toxicity, the animal model Caenorhabditis Web( d) The MARINE POLLUTANT mark is not required ( 1) On single packagings or combination packagings where each single package or each inner packaging of combination packagings has: ( i) A net quantity of 5 L (1.3 gallons) or less for liquids; or ( ii) A net Exposure to large amounts of lindane can negatively affect the nervous system, producing a range of symptoms from headache and dizziness to seizures, convulsions and more rarely death. This produces toxic and corrosive fumes including chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). Tremor. Gyceril PABA. Lindane in soil can leach to surface and even ground water and can bioaccumulate in the food chain. laura velasquez wedding, brookwood village closing, knight rider mustang body kit,

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